SYLLABUS
PHARMACEUTICAL CHEMISTRY
UNIT – I
INTRODUCTION
Important terminologies-drug, pharmacognosy, pharmacy,
pharmacology, pharamacodynamics, pharmacokinetics, clinical
pharmacology, pharmacotherapeutics, chemotherapy, toxicology,
pharmacophere, antimetabolitics, mutation, bacteria, virus, fungi,
actinomyocies, vaccines, pharmacopeia, posology and therpeutic index.
Sources of drugs-dosage forms-bio availability-routes of administrationabsorption,
distribution and elmination of drugs-drug metabolismprescription
terms.
STRUCTURE AND PHARMACOLOGICAL ACTIVITY
Effect of – unsaturation, chain, length, isomerism; groups-halogens
amino, nitro, nitric, cyane, acidic, aldehydic, keto, hydroxyl and alkyl
groups.
DEVELOPMENT OF DRUGS
Development of a drug-classic steps-lead compounds-comparison of
traditional and modern methods of development of drugs-drug design
by method of variation-disjunction and conjunction methods.
UNIT – II
INDIAN MEDICINAL PLANTS
Some important Indian medicinal plants-tulsi, neem, kizhanelli, mango,
semparuthi, adadodai, turmeric and thoothuvalai-uses.
COMMON DISEASES AND THEIR TREATMENT
Causes, prevention and treatment of the following diseases:
Insect borne diseases-malaria, filariasis, plague; Air borne diseasesdiphtheria,
whooping cough, influenza, measles, mumps, common cold,
tuberculosis; Water borne diseases-cholera, typhoid, dysentry.
Digestive system-jaundice; Respiratory system-asthma, Nervous
system-epilepsy.
ANTIBIOTICS
Definition-classification-structure and therapeutic uses of
chloramphenicol, penicillins, structure activity relationship of
erythromycin, tetracycline, rifamycin.
UNIT – III
DRUGS FOR MAJOR DISEASES
Cancer-common causes-chemotherapy-anti neoplastic agentsclassification
-adverse effects of cytotoxic agents; alkylating agentschlorambucil;
anti metabolites-methotrexate, fluouracil; Vinca
alkaloids-vinecristine, vinblastine. Diabetes-types-management of
diabetes-insulin; oral hypoglycemic agents-sulphonyl ureaschlorpropamide;
biguanides-metformin-thiazolidinediones.
Cardiovascular drugs-cardio glycosides; anti arrhythmic agentsquinidine,
propranolol hydrochloride; anti-hypertensive drugs-
Aldomet, pentoliniumtartarate; vasodilator-tolazoline hydrochloride,
sodium nitroprusside. AIDS – causes, symptoms and prevention-anti
HIV drugs-AZT, DDC.
UNIT – IV
ANALGESICS AND ANTIPYRETIC AGENTS
Classification-action of analgesics-narcotic analegesics-morphine;
synthetic analgesics-pethidine, methadone; antipyretic analgesicssaliecylic
acid derivatives, indolyl derivatives, p-aminophenol
derivatives.
ANAESTHICS
Definition, characteristics, classification-general anaesthetics-volatile
anaesthetics-nitrous oxide, ethers, cyclopropane, chlorogorm,
halothane, trichloro ethylene-storage, advantages and disadvantages;
non-volatile anaesthetics-thiopental sodium; local anaestheticsrequistics-
advantages-esters-cocaine, benzocaine;amides-lignocaine,
cinchocaine.
BLOOD AND HAEMOTOLOGICAL AGENTS
Blood-composition, grouping-physiological functions of plasma
proteins-mechanism of clotting; Coagulants-vitamin K, protamine
sulphate, dry thrombin, Anti coagulants-coumarins, citric acid and
heparin; antifibrinolytic agents-aminocaproic acid and tranexamic acid.
Anaemia-causes, types and control-anti anaemic drugs.
UNIT – V
CLINICAL CHEMISTRY
Blood tests-blood count-complete haemotogram-Hb, RBC, GTT, TC,
DC, platelets, PCV, ESR; bleeding and clotting time-glucose tolerance
test.
SIGNIFICANCE OF CLINICAL TESTS
Serum electrolytes-blood Glucose-orthotoluidine method; Renal
functions tests-blood urea, creatinine; liver function tests-serum
proteins, albumin globulin ratio, serum, bilirubin, enzymes SGOT,
SGPT; lipid profile-cholesterol, triglycerides, HDL, LDL, coronary risk
index. Urine examination-pH, tests for glucose, albumin and bile
pigment.